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(S)-(+)-Dimethindene maleate
CAS No. 136152-65-3
(S)-(+)-Dimethindene maleate ( —— )
产品货号. M33918 CAS No. 136152-65-3
(S)-(+)-Dimethindene maleate 是一种有效的选择性毒蕈碱 M2 受体拮抗剂 (pA2 = 7.86/7.74; pKi = 7.78)。(S)-(+)-Dimethindene maleate 对毒蕈碱 M1 (pA2 = 6.83/6.36; pKi = 7.08)，M3 (pA2 = 6.92/6.96; pKi = 6.70)和 M4 (pKi = 7.00) 受体的亲和力较低。(S)-(+)-Dimethindene maleate 也是一种组胺 H1 受体 (histamine H1 receptor) 拮抗剂 (pA2 = 7.48)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥649 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称(S)-(+)-Dimethindene maleate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述(S)-(+)-Dimethindene maleate 是一种有效的选择性毒蕈碱 M2 受体拮抗剂 (pA2 = 7.86/7.74; pKi = 7.78)。(S)-(+)-Dimethindene maleate 对毒蕈碱 M1 (pA2 = 6.83/6.36; pKi = 7.08)，M3 (pA2 = 6.92/6.96; pKi = 6.70)和 M4 (pKi = 7.00) 受体的亲和力较低。(S)-(+)-Dimethindene maleate 也是一种组胺 H1 受体 (histamine H1 receptor) 拮抗剂 (pA2 = 7.48)。
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产品描述(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
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体外实验Cell Viability Assay Cell Line:Mouse EPS cells Concentration:2 μM Incubation Time:1 hour Result:Significantly impaired the developmental potency of mEPS cells.
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体内实验——
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同义词——
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通路Cell Cycle/DNA Damage
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靶点AChR
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受体AChR | Histamine Receptor
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研究领域——
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适应症——
化学信息
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CAS Number136152-65-3
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分子量408.49
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分子式C24H28N2O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (244.80 mM; 超声助溶 )
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SMILESOC(=O)\C=C/C(O)=O.C[C@@H](C1=C(CCN(C)C)Cc2ccccc12)c1ccccn1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Pfaff O, et al. The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur J Pharmacol. 1995;286(3):229-240.?
