PAOPA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PAOPA 是一种 L-脯氨酸-L-亮氨酸-甘氨酸酰胺 (PLG) 肽模拟物，是多巴胺 D2 受体的变构调节剂。PAOPA 可有效减轻精神分裂症啮齿动物模型的行为异常。PAOPA 增加高亲和力多巴胺 D2 受体，促其进激动剂结合而发挥作用。

PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists.

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PAOPA (1 mg/kg; i.p.; once daily for 45 d) in chronic administration induces increased expression of D2 receptor regulation and downstream molecules (including GRK2, arrestin-3, and extracellular receptor kinase ERK 1/2) in mice.

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Others

Other Targets

Others

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114200-31-6

254.29

C11H18N4O3

>98% (HPLC)

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N(C(=O)[C@@H]1CCCN1)[C@H]2C(=O)N(CC(N)=O)CC2

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(-20℃)

With Ice Pack

≥ 2 years