IPAG

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IPAG 是一种有效的 sigma-1 受体拮抗剂，pKi 为 4.3 [1] 。 IPAG 可诱导细胞凋亡 (apoptosis) 。

IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3. IPAG induces apoptosis.

Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells.IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass.IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1.Cell Viability Assay Cell Line:T47D cells Concentration:10 μM Incubation Time:24 hours Result:The mean forward scatter height (FSC-H) of DMSO (control) measured 412±5, whereas the mean FSC-H of IPAG treated cells was 390±4. Western Blot Analysis Cell Line:T47D cells Concentration:10 μM Incubation Time: Result:Decreased levels of phospho-threonine 389-p70S6Kinase (P-S6K), phospho-serine 235/236-ribosomal S6 (P-S6), and phospho-serine 65-4E-BP1 (P-4E-BP1).

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Endocrinology/Hormones

Opioid Receptor

Opioid Receptor

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193527-91-2

395.28

C17H22IN3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 8.33 mg/mL (21.07 mM; ultrasonic and adjust pH to 3 with 1M HCl and heat to 60°C )

Ic1ccc(NC(=N)NC2C3CC4CC(C3)CC2C4)cc1

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(-20℃)

With Ice Pack

≥ 2 years