Imiquimod maleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Imiquimod maleate (R 837 maleate) 是一种 toll 样受体7 (TLR7) 激动剂，作为一种免疫反应修饰剂。Imiquimod maleate 在体内表现出抗病毒和抗肿瘤作用。Imiquimod maleate 可用于外生殖器、肛周疣、癌症和 COVID-19 的研究。

Imiquimod maleate (R 837 maleate), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the research of external genital, perianal warts, cancer and COVID-19.

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In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secretecytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α.

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Autophagy

Autophagy

Autophagy | TLR | HSV | SARS-CoV

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896106-16-4

356.38

C18H20N4O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (70.15 mM; 超声助溶 (<60°C)

C(=C\C(O)=O)\C(O)=O.C(C(C)C)N1C=2C=3C(N=C(N)C2N=C1)=CC=CC3

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(-20℃)

With Ice Pack

≥ 2 years