FFN 511

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FFN511 是一种靶向神经元囊泡单胺转运体 2 (VMA T2) 的荧光假神经递质 (FFNs)。FFN511 可抑制 5-羟色胺与含 VMA T2 的膜结合，其 IC50 值为 1 μM。FFN511 能直接反映细胞外渗过程中的释放动态，可用于标记活体皮质-纹状体急性切片中的多巴胺能神经末梢。

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 μM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices.

FFN511 (350 nM; 30 min) accumulats in a pattern consistent with LDCVs in cultured mouse chromaffin cells, and the accumulation is abolished by the lipophilic base chloroquine.Cell Viability Assay Cell Line:mouse chromaffin cells Concentration:350 nM Incubation Time:30 min Result:Accumulated in cultured mouse chromaffin cells (the same as LDCVs), and the accumulation could be abolished by the lipophilic base chloroquine, which collapses the vesicle pH gradient.

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Others

Other Targets

Others

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1004548-96-2

284.35

C17H20N2O2

>98% (HPLC)

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O=C1OC2=C(C=C3C4=C2CCCN4CCC3)C(=C1)CCN

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(-20℃)

With Ice Pack

≥ 2 years