S-Methylisothiourea sulfate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

S-Methylisothiourea sulfate 是一种高效的，选择性的，竞争性的诱导型一氧化氮合酶 (iNOS) 抑制剂。S-Methylisothiourea sulfate 在感染性休克的啮齿动物模型中发挥有益作用。

S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock.

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Animal Model:Male Wistar rats (260-320 g)Dosage:0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg Administration:Intravenous injection Result:Caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats; Inhibited iNOS activity measured in homogenates of lung.

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Immunology/Inflammation

NOS

NOS | HSV | NO Synthase

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867-44-7

139.18

C2H6N2S·1/2H2O4S

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 65 mg/mL (467.02 mM; 超声助溶) DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

CSC(N)=N.CSC(N)=N.OS(O)(=O)=O

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(-20℃)

With Ice Pack

≥ 2 years