MG-115

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MG-115 是一种有效和可逆的蛋白酶体抑制剂，对 20S 和 26S 蛋白酶体的 Ki 值分别为 21 nM 和 35 nM。MG-115 特异性抑制蛋白酶体的胰凝乳蛋白酶样活性，诱导 p53 依赖性细胞凋亡。

MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis.

MG-115 (0.1-10 μM; 24 h) dose-dependently decreases the viability of HepG2 cells.MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK18 DNA condensates.Cell Viability Assay Cell Line:HepG2 cells Concentration:0.1, 1, 2, 5, 10 μM Incubation Time:24 hoursResult:Dose-dependently decreased cell viability.Inhibited the proteasomal activity, with an IC50 of 2?μM.

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Proteasome/Ubiquitin

Proteasome

Proteasome

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133407-86-0

461.59

C25H39N3O5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (216.64 mM; 超声助溶 (<60°C)

CCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C=O

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(-20℃)

With Ice Pack

≥ 2 years