Amlodipine maleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Amlodipine maleate 是二氢吡啶类钙通道 (calcium channel) 阻滞剂，作为一种具有口服活性的抗心绞痛试剂 (antianginal agent)。Amlodipine maleate 阻断了电压依赖性的 L 型钙通道，从而抑制了钙离子内流。Amlodipine maleate 可用于高血压和癌症的研究。

Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.

Amlodipine maleate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively.Amlodipine maleate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells.Amlodipine maleate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.

Amlodipine maleate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.Amlodipine maleate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice.Animal Model:ATP2B1loxP/loxP mice Dosage:5 mg/kg/day Administration:Subcutaneously implanted osmotic pump for 2 weeksResult:Significantly decreased the blood pressure.

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GPCR/G Protein

Calcium Channel

Calcium Channel

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88150-47-4

524.95

C24H29ClN2O9

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 120 mg/mL (228.59 mM; 超声助溶 )

C(=C\C(O)=O)\C(O)=O.C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1COCCN)C2=C(Cl)C=CC=C2

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(-20℃)

With Ice Pack

≥ 2 years