L-Homocysteine thiolactone hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

L-Homocysteine thiolactone hydrochloride是同型半胱氨酸的分子内硫酯; 防止同型半胱氨酸转化成蛋白质。

L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of homocysteine; prevents translational incorporation of homocysteine into proteins.

In all cell types, from bacterial to human, homocysteine is metabolized to homocysteine thiolactone by methionyl-tRNA synthetase. Elevated levels of homocysteine are an independent risk factor for cardiovascular disease in humans. Homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, a reactive thioester. This conversion occurs in all human cell types, including endothelial cells. Homocysteine thiolactone induces cell death and features of apoptosis including increased phosphotidylserine exposure on the membrane surface, increased apoptotic cells with hypoploid DNA contents, and internucleosomal DNA fragmentation in HL-60 cells. Homocysteine thiolactone is cytotoxic and capable of promoting cell death, as measured by caspase-3 activation and DNA fragmentation. HcyT strongly activates IL-8 release.

Homocysteine thiolactone is toxic, induces epileptic seizures in rodents, and has been implicated in Alzheimer’s disease. Homocysteine thiolactone induces two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. The grade of seizures is dose dependent.

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Others

Other Targets

Others

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31828-68-9

153.63

C4H8ClNOS

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : ≥ 23 mg/mL (149.71 mM)

N[C@@H]1C(=O)SCC1.Cl

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(-20℃)

With Ice Pack

≥ 2 years