3-Phosphoglyceric acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3-Phosphoglyceric acid 是一种糖酵解和卡尔文循环中的代谢中间体。3-Phosphoglyceric acid 可参与肺泡巨噬细胞的表观遗传调控。

3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.

3-Phosphoglyceric acid (400 μM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed.3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages.In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation. RT-PCR Cell Line:Bone marrow-derived macrophages (BMDMs) Concentration:400 μM Incubation Time:24 hours Result:Enhanced Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification was also reversed.

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Others

Other Targets

Others

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820-11-1

186.06

C3H7O7P

>98% (HPLC)

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O=C(O)C(O)COP(=O)(O)O

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(-20℃)

With Ice Pack

≥ 2 years