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UPGL00004
CAS No. 1890169-95-5
UPGL00004 ( —— )
产品货号. M33526 CAS No. 1890169-95-5
UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂 (IC50=29 nM; Kd=27 nM)。UPGL00004 强烈抑制高度侵袭性三阴性乳腺癌细胞系的增殖。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥426 | 有现货 |
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| 10MG | ￥758 | 有现货 |
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| 25MG | ￥1479 | 有现货 |
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| 50MG | ￥2186 | 有现货 |
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| 100MG | ￥3087 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥500 | 有现货 |
|
生物学信息
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产品名称UPGL00004
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂 (IC50=29 nM; Kd=27 nM)。UPGL00004 强烈抑制高度侵袭性三阴性乳腺癌细胞系的增殖。
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产品描述UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines.
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体外实验UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively.
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体内实验The combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight)via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model.
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同义词——
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通路Others
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靶点Other Targets
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受体Glutaminase
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研究领域——
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适应症——
化学信息
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CAS Number1890169-95-5
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分子量534.66
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分子式C25H26N8O2S2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 125 mg/mL (233.79 mM; 超声助溶 )
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SMILESO=C(Cc1ccccc1)Nc1nnc(NC2CCN(CC2)c2nnc(NC(=O)Cc3ccccc3)s2)s1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Huang Q, et al. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J Biol Chem. 2018 Mar 9;293(10):3535-3545.?
产品手册
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