Ro 90-7501

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ro 90-7501 是一种淀粉样 β42 (Aβ42) 原纤维组装抑制剂，可降低 Aβ42 诱导的细胞毒性 (EC50 为 2 μM)。Ro 90-7501 抑制 ATM 磷酸化和 DNA 修复。RO 90-7501选择性增强 TLR3和 RLR 配体诱导的 IFN-β 基因表达和抗病毒反应。Ro 90-7501 还以 TPR 依赖性方式抑制蛋白磷酸酶 5 (PP5)，并对宫颈癌细胞具有显着的放射增敏作用。

Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner.Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.

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Animal Model:Female BALB/c nude mice (8-week-old) with HeLa cells underirradiation Dosage:5 μg/g Administration:Intraperitoneal injection; daily; for 21 days Result:Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.

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Cell Cycle/DNA Damage

ATM/ATR

ATM/ATR | Apoptosis | Phosphatase | Gamma-secretase

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293762-45-5

340.38

C20H16N6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 41.67 mg/mL (122.42 mM; 超声助溶 )

NC1=CC=C(C=C1)C1=NC2=C(N1)C=C(C=C2)C1=NC2=C(N1)C=C(N)C=C2

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(-20℃)

With Ice Pack

≥ 2 years