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PK 11195
CAS No. 85532-75-8
PK 11195 ( —— )
产品货号. M33467 CAS No. 85532-75-8
PK 11195 (RP 52028) 是 TSPO 的一个配体，可靶向研究利什曼病，其对 L. amazonensis，L. major 和 L. braziliensis 的 IC50 值分别为 14.2 μM, 8.2 μM, 3.5 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥258 | 有现货 |
|
| 5MG | ￥432 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥468 | 有现货 |
|
生物学信息
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产品名称PK 11195
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PK 11195 (RP 52028) 是 TSPO 的一个配体，可靶向研究利什曼病，其对 L. amazonensis，L. major 和 L. braziliensis 的 IC50 值分别为 14.2 μM, 8.2 μM, 3.5 μM。
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产品描述PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.
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体外实验Median IC50 values for PK 11195 are 14.2 μM for L. amazonensis, 8.2 μM for L. major, and 3.5 μM for L. braziliensis. The selective index value for L. amazonensis is 13.7, indicating the safety of PK 11195 for future testing in mammals. Time-and dose-dependent reductions in the percentage of infected macrophages, the number of parasites per infected macrophage, and the number of viable intracellular parasites are observed. Electron microscopy reveals some morphological alterations suggestive of autophagy. Interestingly, MCP-1 and superoxide levels are reduced in L. amazonensis-infected macrophages treated with PK 11195.
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体内实验——
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同义词——
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通路Microbiology/Virology
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靶点Parasite
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受体Parasite
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研究领域——
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适应症——
化学信息
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CAS Number85532-75-8
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分子量352.86
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分子式C21H21ClN2O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 25 mg/mL (70.85 mM; 超声助溶 )
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SMILESCCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Guedes CES, et al. In vitro evaluation of the anti-leishmanial activity and toxicity of PK-11195. Mem Inst Oswaldo Cruz. 2018 Feb 5;113(4):e170345.?
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