Ly93

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ly93 是一种口服有效的、鞘磷脂合成酶 (SMS2) 的选择性抑制剂，IC50 值为 91 nM。

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM.

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Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice.Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice.Animal Model:C57BL/6J mice.Dosage:100 mg/kg.Administration:I.G. (gavage) once daily for 7 days.Result:Significantly decreased the plasma SM levels compared with vehicle group.Animal Model:ApoE KO mice (eight-week-old).Dosage:12.5 or 40 mg/kg.Administration:I.G. (gavage) once daily.Result:The levels of ALT and AST in the plasma of apoE KO mice did not show statistic changes when compared with the control group.

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Others

Other Targets

Others

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1883528-69-5

332.4

C21H20N2O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (752.11 mM; 超声助溶 )

CCc1ccccc1COc1ccccc1C(=O)Nc1cccnc1

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(-20℃)

With Ice Pack

≥ 2 years