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GS-9901
CAS No. 1640247-87-5
GS-9901 ( —— )
产品货号. M33371 CAS No. 1640247-87-5
GS-9901 是高度选择性的、口服有效的 PI3Kδ 的抑制剂，其 IC50 值为 1 nM。有用于风湿性关节炎的潜能。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1881 | 有现货 |
|
| 10MG | ￥3306 | 有现货 |
|
| 25MG | ￥5171 | 有现货 |
|
| 50MG | ￥7031 | 有现货 |
|
| 100MG | ￥8883 | 有现货 |
|
| 200MG | ￥12330 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GS-9901
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GS-9901 是高度选择性的、口服有效的 PI3Kδ 的抑制剂，其 IC50 值为 1 nM。有用于风湿性关节炎的潜能。
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产品描述GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC50 of 1 nM. Has potential to treat rheumatoid arthritis.
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体外实验——
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体内实验GS-9901 (0.3/1/3 mg/kg, orally,twice daily for 7 days) demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans.Animal Model:Female Lewis rats with established collagen-induced arthritis (CIA).Dosage:0.3 mg/kg, 1 mg/kg, and 3 mg/kg.Administration:Orally, twice-daily for 7 days starting on the 10th day after the second collagen immunization.Result:Demonstrated significant reduction in ankle swelling in rats treated with 0.3 mg/kg 35 (31% reduction), 1 mg/kg 35 (67%), and 3 mg/kg 35 (65%). Plasma concentrations measured on day 7 (12 h after last dose) were consistent with maintaining approximately 60%, 80%, and >90% inhibition of PI3Kδ at 0.3, 1.0, and 3 mg/kg doses, respectively, at trough levels.
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同义词——
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通路PI3K/Akt/mTOR signaling
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靶点PI3K
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受体PI3K
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研究领域——
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适应症——
化学信息
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CAS Number1640247-87-5
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分子量477.88
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分子式C22H17ClFN9O
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纯度>98% (HPLC)
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溶解度——
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SMILES[C@@H](NC=1C(C#N)=C(N)N=C(N)N1)(C=2N(C(=O)C=3C(N2)=C(F)C=CC3Cl)C=4C=CC=NC4)C5CC5
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Patel L, et al. Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability. J Med Chem. 2016 Oct 13;59(19):9228-9242.?
