Barbadin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Barbadin 是一种选择性 β-arrestin/β2-adaptin 相互作用抑制剂，β-arrestin1和 β-arrestin2 的 IC50 值分别为 19.1 μM 和 15.6 μM。Barbadin 阻断激动剂促进 β2-adrenergic, V2-vasopressin 和 angiotensin-II type-1 受体的内吞作用。Barbadin 可诱导凋亡。

Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1?μM for β-arrestin1 and 15.6?μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis.

Barbadin (4 h) treatment reduces cell viability and induces apoptosis.?Barbadin (2 h) treatment arrests breast cancer cells in G0/G1 phase.Apoptosis Analysis Cell Line:MDA MB-231 cells Concentration:Incubation Time:4 hoursResult:Exhibited morphological characteristics of apoptosis including shrinkage, rounding and detachment, the percent of cell viability was reduced to 69.1% and apoptosis was developed in 29.9% of cells starved with EBSS (Earle’s balanced salt solution).Cell Cycle AnalysisCell Line:MDA MB-231 cells Concentration:Incubation Time:2 hours Result:Arrested 63.7% of cells in G0/G1 phase.

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Others

Other Targets

Arrestin

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356568-70-2

333.41

C19H15N3OS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (149.97 mM; 超声助溶 )

Nn1cnc2scc(-c3ccc(Cc4ccccc4)cc3)c2c1=O

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(-20℃)

With Ice Pack

≥ 2 years