SLF

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SLF 是 FK506 结合蛋白 (FKBP) 的合成配体，对 FKBP51 的亲和力为 3.1 μM，对 FKBP12 的 IC50 为 2.6 μM，可用于合成 PROTAC 分子。

SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC.

Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation.

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Others

Other Targets

FKBP | Ligands for Target Protein for PROTAC

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195513-96-3

524.65

C30H40N2O6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (190.60 mM; 超声助溶 (<60°C)

C(C(C(CC)(C)C)=O)(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC(N)=CC=C3)=O)CCCC1

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(-20℃)

With Ice Pack

≥ 2 years