SLF ( —— )

产品货号. M33233 CAS No. 195513-96-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SLF
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SLF 是 FK506 结合蛋白 (FKBP) 的合成配体，对 FKBP51 的亲和力为 3.1 μM，对 FKBP12 的 IC50 为 2.6 μM，可用于合成 PROTAC 分子。
产品描述

SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC.
体外实验

Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation.
体内实验

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同义词

——
通路

Others
靶点

Other Targets
受体

FKBP | Ligands for Target Protein for PROTAC
研究领域

——
适应症

——

CAS Number

195513-96-3
分子量

524.65
分子式

C30H40N2O6
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (190.60 mM; 超声助溶 (<60°C)
SMILES

C(C(C(CC)(C)C)=O)(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC(N)=CC=C3)=O)CCCC1
化学全称

——

1. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425.?

计算器

产品手册

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