(+)-Tetrabenazine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) 是一个可逆转的VMAT-2的抑制剂。

(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2),inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein. (+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. In vivo:0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.

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Membrane Transporter/Ion Channel

Monoamine Transporter

Monoamine Transporter

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1026016-83-0

317.42

C19H27NO3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 16.67 mg/mL (52.52 mM; 超声助溶 )

[H][C@]12CC(=O)[C@H](CC(C)C)CN1CCc1cc(OC)c(OC)cc21

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(-20℃)

With Ice Pack

≥ 2 years