SR59230A hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SR59230A hydrochloride 是一种有效，选择性的，可透过血脑屏障的 β3-肾上腺素能受体 (β3-adrenergic receptor) 拮抗剂，对 β3，β1 和 β2 受体的 IC50 分别为 40、408 和 648 nM。

SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.

Cell Viability Assay Cell Line:Three different neuroblastoma (NB) cell lines, one murine (Neuro-2A) and two human (SK-N-BE(2), BE(2)C) Concentration:100 nM, 1 μM, 5 μM, 10 μM, and 50 μM Incubation Time:24 hours Result:Reduced cell viability in a dose-dependent manner, with significant effect at a concentration limit over 1?μM for Neuro-2A cells and 5?μM for SK-N-BE(2) and BE(2)C).

Animal Model:Male C-57BL6J wild-type mice (22-35 g)Dosage:0.5 or 5 mg/kg Administration:Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg).Result:Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism.

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GPCR/G Protein

Adrenergic Receptor

Adrenergic Receptor

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1135278-41-9

361.91

C21H28ClNO2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (690.78 mM; 超声助溶 ) H2O 中的溶解度 : 2.5 mg/mL (6.91 mM; 超声助溶)

N(C[C@@H](COC1=C(CC)C=CC=C1)O)[C@@H]2C=3C(CCC2)=CC=CC3.Cl

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(-20℃)

With Ice Pack

≥ 2 years