OSMI-3 ( —— )

产品货号. M33048 CAS No. 2260791-13-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

OSMI-3
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

OSMI-3 (Compound 2b) 是一种有效，持久且可渗透细胞的 O-GlcNAc 转移酶 (OGT) 抑制剂。细胞包含部分剪接的 OGT 转录本的核库，OSMI-3 增加了细胞中保留的内含子剪接。
产品描述

OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells.
体外实验

OSMI-3 (Compound 2b; 20-50 μM; 4-24 hours; HCT116 cells) treatment significantly reduces O-GlcNAc levels, and has more sustained cellular effects than OSMI-2.A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 in cells treated with OSMI-3 (Compound 2b) is observed. Because OGT knockdown is known to decrease cell proliferation, the effects of OSMI-3 on cell growth in culture over 96h is also monitored. Although there is no evidence of apoptosis, the reduced growth of cells over time is observed, consistent with the knockdown results.Western Blot Analysis Cell Line:HCT116 cells Concentration:20 μM, 40 μM, 50 μM Incubation Time:4 hours, 24 hours Result:Reduced O-GlcNAc levels.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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CAS Number

2260791-13-5
分子量

669.77
分子式

C32H35N3O9S2
纯度

>98% (HPLC)
溶解度

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SMILES

[C@@H](C(N(CC1=CC=CS1)CC(OCC)=O)=O)(NS(=O)(=O)C=2C=C3C(=CC2)NC(=O)C=C3)C4=C(OCCCC(OCC)=O)C=CC=C4
化学全称

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1. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.?

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