Norbinaltorphimine dihydrochloride ( —— )

产品货号. M33039 CAS No. 113158-34-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Norbinaltorphimine dihydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Norbinaltorphimine dihydrochloride是一种有效的和选择性的κ阿片受体 (κ opioid receptor) 拮抗剂。
产品描述

Norbinaltorphimine dihydrochloride is a potent and selective κ opioid receptor antagonist.
体外实验

Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively.
体内实验

Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement.
同义词

——
通路

Endocrinology/Hormones
靶点

Opioid Receptor
受体

Opioid Receptor
研究领域

——
适应症

——

CAS Number

113158-34-2
分子量

734.71
分子式

C40H45Cl2N3O6
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (136.11 mM; 超声助溶 ) H2O 中的溶解度 : 33.33 mg/mL (45.36 mM; 超声助溶)
SMILES

Cl.Cl.[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c4C[C@@]5(O)[C@@]6([H])Cc7ccc(O)c8O[C@@]([H])(c4[nH]c21)[C@]5(CCN6CC1CC1)c78)ccc3O
化学全称

——

1. Birch PJ, et al. Norbinaltorphimine: antagonist profile at kappa opioid receptors. Eur J Pharmacol. 1987 Dec 15;144(3):405-8.?

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