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LY2444296
CAS No. 1346133-11-6
LY2444296 ( —— )
产品货号. M33001 CAS No. 1346133-11-6
LY2444296 是一种有口服生物活性、高亲和力、选择性的短效的 KOPR 拮抗剂，其 Ki 值为 ~1 nM。LY2444296 具有抗焦虑样的作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥311 | 有现货 |
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| 10MG | ￥487 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥363 | 有现货 |
|
生物学信息
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产品名称LY2444296
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LY2444296 是一种有口服生物活性、高亲和力、选择性的短效的 KOPR 拮抗剂，其 Ki 值为 ~1 nM。LY2444296 具有抗焦虑样的作用。
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产品描述LY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antagonist, with a Ki value of ～1 nM. LY2444296 exhibits anti-anxiety like effects.
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体外实验——
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体内实验LY2444296 displays anti-anxiety like effects in the EPM test.LY2444296 (3 mg/kg; i.p.; 30 min before U69,593 administration) prevents behavioral and neuroendocrine effects caused by the reference kappa agonist U69,593 in cocaine-na?ve rats.LY2444296 reduces anxiety-like and depressive-like behaviors, as well as CORT release, in rats tested after chronic extended access cocaine self-administration, but not in cocaine-na?ve rats.Animal Model:Adult male Sprague Dawley rats (240–250 g)Dosage:3 mg/kg Administration:Injected intraperitoneally; 30 min before U69,593 administration Result:Prevented behavioral and neuroendocrine effects caused by U69,593 in cocaine-na?ve rats.
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同义词——
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通路Endocrinology/Hormones
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靶点Opioid Receptor
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受体Opioid Receptor
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研究领域——
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适应症——
化学信息
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CAS Number1346133-11-6
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分子量408.44
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分子式C24H22F2N2O2
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纯度>98% (HPLC)
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溶解度In Vitro:?Ethanol 中的溶解度 : 27.5 mg/mL (67.33 mM; 超声助溶)
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SMILESNC(=O)c1ccc(Oc2ccc(CN3CCC[C@H]3c3cccc(F)c3)cc2)c(F)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Huang P, et al. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neurosci Lett. 2016 Feb 26;615:15-20.?
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