CRTh2 antagonist 2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CRTh2 antagonist 2 是一种有效的选择性 CRTH2 抑制剂，对 CRTH2 的 IC50 值为 ≤10 nM，详细信息请参考专利 US20140148470A1 的化合物 Example 1。CRTh2 antagonist 2 可用于雄激素性脱发的研究。

CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia.

CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS).

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Cell Cycle/DNA Damage

GPR

GPR

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780763-95-3

474.94

C26H23ClN4O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (263.19 mM; 超声助溶 )

CN(C)c1nc(Cc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)nc(Cl)c1CC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years