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CDK4/6/1 Inhibitor
CAS No. 2099128-41-1
CDK4/6/1 Inhibitor ( —— )
产品货号. M32833 CAS No. 2099128-41-1
Crozbaciclib (CDK4/6/1 Inhibitor) 是 CDK4/6 的抑制剂，IC50 值分别为 3 和 1 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥4997 | 有现货 |
|
| 10MG | ￥6831 | 有现货 |
|
| 25MG | ￥9951 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CDK4/6/1 Inhibitor
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Crozbaciclib (CDK4/6/1 Inhibitor) 是 CDK4/6 的抑制剂，IC50 值分别为 3 和 1 nM。
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产品描述Crozbaciclib (CDK4/6/1 Inhibitor) is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively.
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体外实验Crozbaciclib is a potent anti-proliferative agent that arrests U87MG cell line exclusively in G1 (IC50=15.3 ± 2.9 nM in the anti-proliferation assay). Crozbaciclib (13.72 nM; 24 h) significantly increases in the percentage of cells in G1 in U87MG cells.
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体内实验Crozbaciclib (3.125-50 mg/kg; ) has tumor growth inhibition values ranging from 62% to 99% in an orthotopic xenograft mouse model of glioblastoma multiforme. And Crozbaciclib results insignificant body weight loss. Crozbaciclib increases life span based on the median survival time of vehicle-treated animals in mice is significant at 162%, at a dose of 50 mg/kg.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点CDK
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受体CDK
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研究领域——
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适应症——
化学信息
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CAS Number2099128-41-1
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分子量488.57
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分子式C28H30F2N6
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纯度>98% (HPLC)
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溶解度——
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SMILESCC=1C2(C=3C(N1)=C(F)C=C(C3)C4=NC(NC5=CC=C(C=N5)C6CCN(C)CC6)=NC=C4F)CCCC2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yin L, et al. A highly potent CDK4/6 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy. Eur J Med Chem. 2018 Jan 20;144:1-28.?
产品手册
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