CDK4/6/1 Inhibitor

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Crozbaciclib (CDK4/6/1 Inhibitor) 是 CDK4/6 的抑制剂，IC50 值分别为 3 和 1 nM。

Crozbaciclib (CDK4/6/1 Inhibitor) is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively.

Crozbaciclib is a potent anti-proliferative agent that arrests U87MG cell line exclusively in G1 (IC50=15.3 ± 2.9 nM in the anti-proliferation assay). Crozbaciclib (13.72 nM; 24 h) significantly increases in the percentage of cells in G1 in U87MG cells.

Crozbaciclib (3.125-50 mg/kg; ) has tumor growth inhibition values ranging from 62% to 99% in an orthotopic xenograft mouse model of glioblastoma multiforme. And Crozbaciclib results insignificant body weight loss. Crozbaciclib increases life span based on the median survival time of vehicle-treated animals in mice is significant at 162%, at a dose of 50 mg/kg.

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Cell Cycle/DNA Damage

CDK

CDK

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2099128-41-1

488.57

C28H30F2N6

>98% (HPLC)

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CC=1C2(C=3C(N1)=C(F)C=C(C3)C4=NC(NC5=CC=C(C=N5)C6CCN(C)CC6)=NC=C4F)CCCC2

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(-20℃)

With Ice Pack

≥ 2 years