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BMT-124110
CAS No. 1679371-59-5
BMT-124110 ( —— )
产品货号. M32813 CAS No. 1679371-59-5
BMT-124110 是一种有效的选择性 AAK1 抑制剂，IC50 为 0.9 nM。 BMT-124110 显示出抗伤害感受活性。BMT-090605 抑制 BMP-2 诱导蛋白激酶 (BIKE) 和细胞周期蛋白 G 相关激酶 (GAK)，IC50 分别为 17 和 99 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥5292 | 有现货 |
|
| 10MG | ￥7401 | 有现货 |
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| 25MG | ￥10695 | 有现货 |
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| 50MG | ￥14508 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥6346 | 有现货 |
|
生物学信息
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产品名称BMT-124110
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BMT-124110 是一种有效的选择性 AAK1 抑制剂，IC50 为 0.9 nM。 BMT-124110 显示出抗伤害感受活性。BMT-090605 抑制 BMP-2 诱导蛋白激酶 (BIKE) 和细胞周期蛋白 G 相关激酶 (GAK)，IC50 分别为 17 和 99 nM。
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产品描述BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively.
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体外实验BMT-124110 shows a cellular IC50 of 3.2±1.4 nM for AAK1.
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体内实验BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals.
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同义词——
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通路Others
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靶点Other Targets
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受体AAK1 (AP2 associated kinase 1)
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研究领域——
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适应症——
化学信息
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CAS Number1679371-59-5
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分子量369.46
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分子式C21H27N3O3
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纯度>98% (HPLC)
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溶解度——
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SMILESN(C(C)=O)C=1C=C2C=3C(=CC(OC[C@@](CC(C)C)(C)N)=CC3)OCC2=CN1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.?
产品手册
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