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BAY-678
CAS No. 675103-36-3
BAY-678 ( —— )
产品货号. M32798 CAS No. 675103-36-3
BAY-678 是具有口服生物活性的、高效的、选择性的、人中性粒细胞弹性蛋白酶 (HNE) 的细胞渗透性抑制剂，其 IC50 值为 20 nM。BAY-678 也是被基因结构组学联盟 (SGC) 推荐的化学探针。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥330 | 有现货 |
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| 10MG | ￥566 | 有现货 |
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| 25MG | ￥1200 | 有现货 |
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| 50MG | ￥1795 | 有现货 |
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| 100MG | ￥2637 | 有现货 |
|
| 200MG | ￥3573 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥363 | 有现货 |
|
生物学信息
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产品名称BAY-678
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BAY-678 是具有口服生物活性的、高效的、选择性的、人中性粒细胞弹性蛋白酶 (HNE) 的细胞渗透性抑制剂，其 IC50 值为 20 nM。BAY-678 也是被基因结构组学联盟 (SGC) 推荐的化学探针。
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产品描述BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
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体外实验BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. The Ki value of BAY-678 for MNE is 700 nM. BAY-678 is the 4th generation inhibitor of HNE. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). BAY-678 has more than 2,000-fold selectivity in a panel of 21 serine proteases.
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体内实验BAY-678 (17) reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating their anti-inflammatory and anti-remodeling mode of action. Additionally, BAY-678 (17) has shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number675103-36-3
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分子量400.35
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分子式C20H15F3N4O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : ≥ 100 mg/mL (249.78 mM ) Ethanol 中的溶解度 : ≥ 4.76 mg/mL (11.89 mM)
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SMILESCC(=O)C1=C(C)N(C(=O)N[C@@H]1c1ccc(nc1)C#N)c1cccc(c1)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.?
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