Tricetin

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Tricetin is a flavonoid isolated from pomegranate.

Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by activating the Nrf2/HO-1 signaling pathway and blocking mitochondria-dependent apoptotic pathways.Tricetin Inhibits migration and expression of the indicator protease progerin-1 (PS-1) in nasopharyngeal carcinoma through the Akt/GSK-1β pathway.Tricetin inhibits endothelial inflammation induced by oxidized LDL mediated by Egr-1, and protects rat chondrocytes from IL-1β-induced inflammation and apoptosis.Tricetin is an inhibitor of endothelial inflammation induced by oxidized LDL mediated by Egr-1 and protects against IL-1β-induced inflammation and apoptosis.

Tricetin is mainly found in natural plants such as?Ginkgo biloba?L.,?Carica papaya?L. and?Murraya exotica?L.?Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of?C. elegans. Tricetin has?cytostatic?properties and anti-metastatic activity of various?solid tumors.Pretreatment?with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200?μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis.Tricetin (80?μM; for 1, 2 and 4?h) markedly decreased the expressions of p-JNK and p-p38. Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:20, 40, and 80 μM Incubation Time:Pretreatment?for 4?h followed by 6-OHDA (200?μM) for 24?h Result:Significantly increased 6-OHDA-induced SH-SY5Y cells viability.Western Blot Analysis Cell Line:SH-SY5Y cells Concentration:80?μM Incubation Time:1, 2 and 4?h Result:Markedly decreased the expressions of p-JNK and p-p38.?

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Others

Other Targets

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520-31-0

302.2

C15H10O7

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years