Picrotoxinin ( —— )

产品货号. M32101 CAS No. 17617-45-7

COA

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产品名称

Picrotoxinin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.
产品描述

Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.
体外实验

Picrotoxinin (0.001 μM-1 mM; 60-90 s) inhibits the action of GABAA receptor and regulates GABAA modulators in the presence of EC5 GABA at α1β2γ2L GABAA receptors. Cell Viability Assay Cell Line:Xenopus oocytes Concentration:0.001 μM-1 mM Incubation Time:60 and 90 s Result:Dose-dependently inhibited the action of GABAA receptor with an IC50 of 1.15 μM and exhibited the most potent activity compared with bilobalide and ginkgolide B. Inhibited etomidate, propofol, diazepam, thiopentone sodium, loreclezole and allopregnanoloner in the presence of EC5 GABA at α1β2γ2L GABAA receptors with IC50s of 0.55, 0.49, 0.35-0.36, 0.50, 0.14 and 0.44 μM, respectively.
体内实验

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