Withanolide B ( —— )

产品货号. M31674 CAS No. 56973-41-2

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产品名称

Withanolide B
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Withanolide B is a natural product.
产品描述

Withanolide B is a natural product.
体外实验

Withanolide B (1-100 nM; 3-5 days) significantly increases the expression of COL1A1 and RUNX2 genes and proteins in hBMSCs.Withanolide B (1-100 nM; 11 or 3 days) increases the formation of extracellular matrix calcium deposits and increased the activity of alkaline phosphatase (ALP).Withanolide B (1-100 nM; 3-5 days) increases the protein expressions of p-ERK and active β-catenin of hBMSCs.Withanolide B (10-100 μM; 48 h) reverses the Aβ42 aggregation-induced toxicy in SK-N-SH cells.Cell Viability Assay Cell Line:Human bone mesenchymal stem cells Concentration:1, 10, 100 nM Incubation Time:3, 5 days Result:Significantly increased the expression of COL1A1 and RUNX2.
体内实验

Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model. Animal Model:Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect Dosage:10 mg/kg Administration:Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days)Result:Increased the trabecular number, trabecular thickness and the thickness of the cortical bone.
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