Pep2m, myristoylated

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression.

Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression.

Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.

Pep2m, myristoylated (10 μg/20 μL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test. Animal Model:Female and male Long-Evans hooded rats (8 weeks) Dosage:10 μg (in 20 μL)Administration:Intrathecal injection Result:Resulted in an increase in PWTs, in both male and female rats at various time points tested.

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Angiogenesis

PKC

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1423381-07-0

1383.8

C63H118N18O14S

>98% (HPLC)

water:1 mg/mL

[H]N([C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)C(=O)CCCCCCCCCCCCC

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(-20℃)

With Ice Pack

≥ 2 years