MMK 1 ( —— )

产品货号. M30644 CAS No. 271246-66-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MMK 1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.
产品描述

Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.
体外实验

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体内实验

Animal Model:Four-week-old male ddY mice Dosage:10, 100, 1000 pmol/mouse Administration:ICV; 20 min before the testResult:Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse.
同义词

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通路

GPCR/G Protein
靶点

Calcium Channel
受体

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研究领域

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适应症

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CAS Number

271246-66-3
分子量

1610.97
分子式

C75H123N19O18S
纯度

>98% (HPLC)
溶解度

25% ethanol / water:0.50 mg/mL
SMILES

[H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(O)=O
化学全称

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1. Hu et al (2001) Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1. J.Leukoc.Biol. 70 155 PMID:

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