MM 54 ( —— )

产品货号. M30643 CAS No. 1313027-43-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MM 54
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.
产品描述

Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.
体外实验

MM 54 inhibits more than 95% of apelin binding to APLNR at the dose of 10 μM.
体内实验

MM 54 (2 mg/kg, ip, bi-weekly for 4 weeks) possesses anti-tumor activity in glioblastoma models with no obvious toxicity. Animal Model:Tumour-bearing nude-mice.Dosage:2 mg/kg.Administration:Intraperitoneal injection, bi-weekly for 4 weeks.Result:Reduced tumor progression (glioblastoma).
同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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CAS Number

1313027-43-8
分子量

1737.15
分子式

C70H121N29O15S4
纯度

>98% (HPLC)
溶解度

water:2 mg/mL
SMILES

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O
化学全称

——

1. Macaluso et al (2011) Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6 1017 PMID:

计算器

产品手册

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