Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.Pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not enhance pancreatic insulin secretion.

NNC-0640 是人胰高血糖素受体的负变构调节剂，IC50 为 69.2 nM。

GLP-1R modulator C5 是一种变构调节剂，通过跨膜位点增强GLP-1与GLP-1R的结合（EC50 1.59 ± 0.53 μM）。