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GLP-1(7-37)
CAS No. 106612-94-6
GLP-1(7-37) ( —— )
产品货号. M30005 CAS No. 106612-94-6
GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GLP-1(7-37)
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.
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产品描述GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.(In Vivo):GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats. Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM.
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体外实验——
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体内实验GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats.Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM. Animal Model:Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM.Dosage:0.5, 5 or 50 pmol/min/kg.Administration:IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp.Result:Produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion.Animal Model:Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variable.rate for 7 hours to maintain plasma glucose concentration at 11 mM.Dosage:5 pmol/min/kg.Administration:IV from 1 hour through 7 hours.Result:Produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle.
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同义词——
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通路GPCR/G Protein
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靶点Glucagon Receptor
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number106612-94-6
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分子量3355.67
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分子式C151H228N40O47
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纯度>98% (HPLC)
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溶解度H2O : 30 mg/mL (8.94 mM; Need ultrasonic and warming)
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SMILES——
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化学全称Sequence:His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004).
