Bavisant

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Bavisant 是一种选择性、口服活性的人类 H3 受体拮抗剂。 Bavisant 可用于作用机制的研究，包括觉醒和认知以及 ADHD 的治疗。

Bavisant is a selective and orally active Human H3 receptor antagonist. Bavisant can be used in research on mechanisms of action, involving wakefulness and cognition and the treatment for ADHD.(In Vivo):Mean change from baseline in the total ADHD-RS-IV score at day 42 (primary efficacy endpoint) was -8.8 in the placebo group versus -9.3, -11.2, and -12.2 in the Bavisant 1 mg/day, 3 mg/day, and 10 mg/day groups, respectively; the change in the 10 mg/day group was not statistically superior to placebo, and hence statistical comparisons of the 1 mg/day and 3 mg/day groups with placebo based on a step-down closed testing procedure were not performed.

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Bavisant increases acetylcholine levels in rat frontal cortex.

JNJ-31001074

GPCR/G Protein

Histamine Receptor

Histamine Receptor

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929622-08-2

329.444

C19H27N3O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (303.55 mM)

O=C(N1CCN(CC1)C1CC1)c1ccc(CN2CCOCC2)cc1

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(-20℃)

With Ice Pack

≥ 2 years