MT-DADMe-ImmA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MT-DADMe-ImmA 是人 5'-甲硫腺苷磷酸化酶 (MTAP, Ki: 90 pM) 的抑制剂。

MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).(In Vitro):Treatment of cultured cells with MTA and MT-DADMe-ImmA inhibit MTAP, increase cellular MTA concentrations, decrease polyamines, and induce apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines. MT-DADMe-ImmA alone does not induce apoptosis in any cell line .(In Vivo):MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA .

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Methylthio-DADMe-Immucillin A | MTDIA

Others

Other Targets

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653592-04-2

293.39

C13H19N5OS

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (340.84 mM)

CSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O

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(-20℃)

With Ice Pack

≥ 2 years