N-Caffeoyltryptophan

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

使用咖啡提取物筛选 N-咖啡酰色氨酸，一种潜在的 Sirt 抑制剂。 N-咖啡酰色氨酸对 Sirt2 的抑制（IC50；8.7 μM）优于 Sirt1（IC50；34μM）。

N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).(In Vitro):In cellular levels,N-Caffeoyltryptophan was able to increase the acetylation of total lysine, cortactin and histone H3 in neuronal NG108-15 cells. In the same cells, the amide also increased the acetylation of lysine (K382) in p53, but not (K305).

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trans-Caffeoyl-L-tryptophan

Chromatin/Epigenetic

Sirtuin

Sirtuin

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109163-69-1

366.373

C20H18N2O5

>98% (HPLC)

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OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)\C=C\c1ccc(O)c(O)c1

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(-20℃)

With Ice Pack

≥ 2 years