Sanguisorbigenin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sanguisorbigenin 是一种天然抗菌剂，可抑制耐甲氧西林金黄色葡萄球菌 (MRSA)。

Sanguisorbigenin is a natural antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA).(In Vitro):Treatment of Sanguisorbigenin with sub-MIC concentrations (1.56-6.25 μg/mL) significantly inhibited the expression of blaR1, mecA, and blaZ in MRSA dose-dependently. The gene expression of mecA is remarkably reduced after the treatment of Sanguisorbigenin. The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decreasing PBP2a expression.

The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL. The expression of blaR1, mecA and blaZ is significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression of mecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decrease PBP2a expression.

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3β-Hydroxyurs-12,19-dien-28-oic acid | Ursa-12,19-dien-28-oic acid |

GPCR/G Protein

Antibacterial

Antibacterial

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6812-98-2

470.68

C30H46O4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (109.97 mM)

CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])C(C)=C(C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]

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(-20℃)

With Ice Pack

≥ 2 years