Primin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Primin 是报春花叶和茎毛状体中的天然产物，具有抗分枝杆菌和强抗肿瘤作用。

Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimycobacterial, and strong antineoplastic actions.(In Vitro):Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 = 0.144 μM) and Leishmania donovani (IC50 = 0.711 μM), and revealed low cytotoxicity (IC50 = 15.4 μM) on mammalian cells. Only moderate inhibitory activity was observed against Mycobacterium tuberculosis, Trypanosoma cruzi, and Plasmodium falciparum.(In Vivo):When tested for in vivo efficacy in a Trypanosoma b. brucei rodent model, Primin failed to cure the infection at 20 mg/kg given intraperitoneally. Primin was too toxic in vivo at a higher concentration (30 mg/kg, injected i.p.) in mice infected with L. donovani.

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Microbiology/Virology

Antifection

Anti-infection

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15121-94-5

208.257

C12H16O3

>98% (HPLC)

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CCCCCC1=CC(=O)C=C(OC)C1=O

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(-20℃)

With Ice Pack

≥ 2 years