Isolicoflavonol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

异黄酮醇可抑制人羧酸酯酶 2 (hCES2A)，而人羧酸酯酶 2 (hCES2A) 是改善伊立替康引发的肠道毒性的关键靶标，伊立替康会导致 50%-80% 接受该抗癌药物的患者出现严重腹泻。

Isolicoflavonol inhibits Human carboxylesterase 2 (hCES2A) which is a key target to ameliorate the intestinal toxicity triggered by irinotecan that causes severe diarrhea in 50%-80% of patients receiving this anticancer agent.(In Vitro):Isolicoflavonol inhibits hCES2A-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM.

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Metabolic Enzyme/Protease

Lipid

Lipid

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94805-83-1

354.358

C20H18O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (282.21 mM)

CC(C)=CCc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O

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(-20℃)

With Ice Pack

≥ 2 years