Beta-Hydroxyisovalerylshikonin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Beta-Hydroxyisovalerylshikonin 是一种蛋白质酪氨酸激酶（例如 v-Src 和 EGFR）的抑制剂，并已被证明可诱导多种人类肿瘤细胞系凋亡。 Beta-Hydroxyisvalerylshikonin 显着降低 HCT116 细胞的活力（IC50 值 = 30.9 μg/mL）。

Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly decreased viability of HCT116 cells (IC50 values = 30.9 μg/mL).(In Vitro):The tyrosine kinase activities of a receptor for EGF (EGFR) and v-Src were strongly inhibited and that of KDR/Flk-1 was weakly inhibited by Beta-Hydroxyisovalerylshikonin. The IC50 values of Beta-Hydroxyisovalerylshikonin for EGFR and v-Src were approximately 0.7 microM and 1 microM, respectively.(In Vivo):In vivo experiments also proved the therapeutic effects of Beta-Hydroxyisovalerylshikonin on OA in mice, and Nrf2 is the target of Beta-Hydroxyisovalerylshikonin.

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β-Hydroxyisovalerylshikonin

Angiogenesis

EGFR

EGFR

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7415-78-3

388.416

C21H24O7

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (25.75 mM)

CC(C)=CC[C@@H](OC(=O)CC(C)(C)O)C1=CC(=O)c2c(O)ccc(O)c2C1=O

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(-20℃)

With Ice Pack

≥ 2 years