3,4-O-Isopropylidene-shikimic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3,4-氧代异丙叉莽草酸具有显着的抗炎、抗血栓、抗氧化、镇痛作用，对三硝基苯磺酸诱发的大鼠实验性结肠炎有保护作用，可能是由于抗氧化作用。

3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimental colitis induced by trinitrobenzenesulfonic acid in rats, probably due to antioxidant action.(In Vitro):3,4-O-Isopropylidene shikimic acid (ISA,1-100 micromol/L) effectively reduced PMN adhesion to TNF-alpha-induced HUVEC with the inhibitory rate from 17.2 % to 53.5 % and exerted no effect on PMN adhesion to normal HUVEC. Adhesion molecule ICAM-1 surface protein and mRNA expression induced by TNF-alpha (400 kU/L) were significantly inhibited by ISA. In addition, the cell viability of HUVEC was unchanged 48 h after treatment with ISA.

——

——

3,4-O-Isopropylidene shikimic acid | 3,4-O-Isopropylidene-shikimic acid

Immunology/Inflammation

NOS

NOS

——

——

183075-03-8

214.2

C10H14O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (466.81 mM)

CC(C)(O[C@H]1[C@@H](C2)O)O[C@@H]1C=C2C(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years