Aurantiamide acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

首次从青霉曲霉的发酵液中分离得到醋酸橙酰胺。 Aurantiamideacetate 是一种选择性的、口服活性的组织蛋白酶抑制剂。 Aurantiamideacetate 具有抗炎活性，可用于炎症性疾病的研究。

Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases.(In Vitro):Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively. (In Vivo):Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.

Aurantiamide acetate inhibits cathepsin L (3.4.22.15) and cathepsin B (3.4.22.1) with IC50?of 12 μM and 49 μM, respectiveiy.

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Asperglaucide

Proteasome/Ubiquitin

Cysteine Protease

Cysteine Protease

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56121-42-7

444.52

C27H28N2O4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (112.48 mM)

CC(OC[C@H](Cc1ccccc1)NC([C@H](Cc1ccccc1)NC(c1ccccc1)=O)=O)=O

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(-20℃)

With Ice Pack

≥ 2 years