021-51111890
购物车（）
sales@molnova.cn
BT173
CAS No. 2232180-74-2
BT173 ( —— )
产品货号. M28979 CAS No. 2232180-74-2
BT173 是一种新型同源结构域相互作用蛋白激酶 2 (HIPK2) 抑制剂，通过抑制 TGF-?1/Smad3 途径减轻肾纤维化。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2774 | 有现货 |
|
| 10MG | ￥4104 | 有现货 |
|
| 25MG | ￥6398 | 有现货 |
|
| 50MG | ￥8677 | 有现货 |
|
| 100MG | ￥11250 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称BT173
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述BT173 是一种新型同源结构域相互作用蛋白激酶 2 (HIPK2) 抑制剂，通过抑制 TGF-?1/Smad3 途径减轻肾纤维化。
-
产品描述BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-?1/Smad3 pathway.(In Vitro):BT173 strongly inhibited the ability of HIPK2 to potentiate the downstream transcriptional activity of Smad3 in kidney tubular cells.?Binding of BT173 to HIPK2 did not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. In vitro, treatment with BT173 inhibited TGF-β1–induced Smad3 phosphorylation and Smad3 target gene expression in human renal tubular epithelial cells. (In Vivo):In vivo, administration of BT173 decreased Smad3 phosphorylation and mitigated renal fibrosis and deposition of extracellular matrix in unilateral ureteral obstruction and Tg26 mouse models of renal fibrosis .
-
体外实验——
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number2232180-74-2
-
分子量382.21
-
分子式C18H12BrN3O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCOC1=CC=C2C=C(C3=NC(C4=CC=C(Br)C=C4)=NO3)C=NC2=C1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Cheng X, Ma S. [Pd(PPh3)4]-catalyzed diastereoselective synthesis of trans-1,2-diazetidines from 2,3-allenyl hydrazines and aryl halides. Angew Chem Int Ed Engl. 2008;47(24):4581-3.
产品手册
关联产品
-
13-Oxyingenol dodeca...
13-Oxyingenol-13-dodecanoate 是一种可从大戟 (Euphorbia kansui) 中分离得到的酯类。13-Oxyingenol-13-dodecanoate 具有抗 HIV-1 活性，EC50 值为 33.7 nM。
-
Pinostilbene
Pinostilbene 明显减弱 6-OHDA 引发的 c-Jun 和 JNK 磷酸化。
-
[Asp371]-Tyrosinase ...
Tyrosinase (369-377,YMDGTMSQV) is derived from the membrane protein tyrosinase by posttranslational conversion of the sequence YMNGTMSQV. Presentation of YMDGTMSQV in cells expressing full-length tyrosinase is TAP-(transporter associated with antigen processing) and proteosome-dependent.
