Almonertinib mesylate ( HS-10296 mesylate )

产品货号. M28940 CAS No. 2134096-06-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Almonertinib mesylate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

甲磺酸阿莫替尼是一种不可逆的 EGFR 酪氨酸激酶抑制剂，对 EGFR 致敏和 T790M 耐药突变具有高选择性。甲磺酸阿莫替尼可用于非小细胞肺癌研究。
产品描述

Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer studies.(In Vitro):Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q.
体外实验

HS-10296 mesylate is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC. Additionaly, HS-10296 mesylate could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q.
体内实验

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同义词

HS-10296 mesylate
通路

Angiogenesis
靶点

EGFR
受体

Na+ channel
研究领域

——
适应症

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CAS Number

2134096-06-1
分子量

621.75
分子式

C31H39N7O5S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 31.25 mg/mL (50.26 mM)
SMILES

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C4CC4)C5=C3C=CC=C5)=N2)=C(OC)C=C1N(CCN(C)C)C)=O.CS(=O)(O)=O
化学全称

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1.Jean-Christophe ANDREZ, et al. Benzenesulfonamide compounds and their use as therapeutic agents. Patent WO2017201468A1.

计算器

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