(E/Z)-Sivopixant

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(E/Z)-Sivopixantis 是一种有效的 P2X3 受体拮抗剂，IC50 = 4 nM。 (E/Z)-Sivopixant 可用于呼吸系统疾病研究。

(E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.

ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors. It has been suggested that it is involved in information transmission in the respiratory organs.

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(E/Z)-S-600918

Membrane Transporter/Ion Channel

P2X Receptor

hPPARα| human PPARγ

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1640808-39-4

507.93

C25H22ClN5O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (196.88 mM)

C(N1C(NC2=CC=C(OC3=CC=CC=N3)C=C2)=NC(=O)N(C[C@@H](C(O)=O)C)C1=O)C4=CC=C(Cl)C=C4

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(-20℃)

With Ice Pack

≥ 2 years