PHD-1-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PHD-1-IN-1 是缺氧诱导因子脯氨酰羟化酶结构域 1 (PHD-1) 的有效抑制剂 (IC50 = 0.034 μM)。

PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).(In Vivo):Administration of PHD-1-IN-1 (3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95.

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PHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95. Animal Model:Male C57BL6 mice Dosage:3 mg/kg (p.o.) or 0.5 mg/kg (i.v.) (Pharmacokinetic Analysis) Administration:PO or IV Result:Had a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95.

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Angiogenesis

HIF/HIF Prolyl-hydroxylase

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2009343-14-8

220.23

C13H8N4

>98% (HPLC)

In Vitro:?DMSO : 195 mg/mL (885.44 mM)

N#Cc(cc1)ccc1-c1cccc2ncnn12

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(-20℃)

With Ice Pack

≥ 2 years