KL201

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KL201 是一种生物钟调节剂，是一种异构体选择性隐花色素 1 (CRY1) 稳定剂。 KL201 延长细胞和组织的昼夜节律周期。

KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues.(In Vitro):KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc, without affecting cellular viability. KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3. KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants.

KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc, without affecting cellular viability.KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3.KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants.

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Others

Other Targets

hLPA5

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302939-48-6

388.28

C17H14BrN3OS

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (643.87 mM)

Brc1ccccc1C(=O)Nc1ncnc2sc3CCCCc3c12

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(-20℃)

With Ice Pack

≥ 2 years