N-piperidine Ibrutinib

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N-piperidine Ibrutinib 是一种有效的 BTK 抑制剂，WT BTK 的 IC50 值分别为 51.0，C481S BTK 的 IC50 值分别为 30.7 nM。

N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.(In Vitro):N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC50s of 374, 162, and 8.3 nM, respectively.

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Tyrosine Kinase

BTK

Nrf2

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330785-90-5

386.45

C22H22N6O

>98% (HPLC)

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Nc1c(c(-c(cc2)ccc2Oc2ccccc2)nn2C3CCNCC3)c2ncn1

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(-20℃)

With Ice Pack

≥ 2 years