IMP-1088

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IMP-1088 是人 N-肉豆蔻酰转移酶 NMT1 和 NMT2 双重的有效抑制剂。

IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.(In Vitro):IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection.IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h.

IMP-1088 (1-1000 nM) prevents virus-induced cytopathic effect (CPE) in a dose-dependent manner with an IC50 of 17 nM. IMP-1088 (125 nM) complete suppresses of new infectious virus with an IC50 of 5.8 nM. IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection. IMP-1088 (50 nM) significantly less enriches multiple N-myristoylated proteins in enriched samples. IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h. IMP-1088 (0.24 nM-1 μM; for 24 hours +24 hours washout) has no long-term effect on cell viability and NMT activity fully recovers by 24 h. IMP-1088 potently blocks a key step in viral capsid assembly by inhibition of co-translational myristoylation of a specific virus-encoded protein (VP0). IMP-1088 blocks neither production of viral RNA, nor translation of rhinovirus polyprotein.

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Others

Other Targets

D4 Receptor

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2059148-82-0

453.53

C25H29F2N5O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (220.49 mM)

Cc1c(CCOc(c(-c(cc2)cc3c2n(C)nc3CN(C)C)ccc2F)c2F)c(C)nn1C

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(-20℃)

With Ice Pack

≥ 2 years